dmm, you are 100% with what's right in this world and your SIL is 100% with what's wrong in this world. My family on all sides have been hit pretty hard by addiction. I can not add to what others have shared in terms that your wife and yourself are extremely wonderful people. My biggest weakness in my life is seeing children sick, suffering or hurting. My worst enemy's child could be sick and I would feel for that child. With that said, your SIL is sick and she is the child of your wife's parents. This must be killing your MIL/FIL.
Isabella is a beautiful girl, and I sit here and type and I am heartbroken how the disease of addiction is greater than the love for Isabella.
Like I said, I have seen addiction ruin families. My uncle was a decorated Green Beret, but he was also a drug addict and a drunk who died on the streets, begging for change to buy booze, at the age of 33. His son, my cousin, passed a few years ago after eating a handful of pills, and his BAC was over .25 when the autopsy results came back. He was 29 years of age when he passed.
Before my uncle passed, all of our lives were in turmoil because of him, we loved him and it killed us to see him like that, but he could not just stay sober. When he passed, our lives became normal again and before he passed, my grandmother prayed that God would make Uncle Tony better, she prayed that God would take his pain and suffering away. Well, God did. Not everything comes gift wrapped and with a big bow.
With the circumstances that we already know, Isabella is at a disadvantage, Isabella has not one, but two genes in her that were passed down by her biological parents, genes of addiction, and Isabella was born addicted to drugs. Isabella will get older and of course, psychologically, she will start to feel and ask herself questions like, "why did my parents give me up", "why didn't my parents love me", "what did I do so wrong". These questions will torment her, and as far as we are all concerned, you/your wife are her parents, and you can help her get through those tough times, and hopefully she has dodged the addiction bullet. I don't want to sound like a downer, but Isabella has a long road ahead of her and she will have many obstacles to overcome. For the Grace of God, she has two of the world's best people looking after her, and for the Grace of God, I pray that Isabella does escape the addiction gene, and you don't have to look at her like you look at SIL #2, because you will see a beautiful person who has succumbed to addiction, much like the woman who gave birth to her, as I am sure that your in-laws see their beautiful baby girl who can't escape the booze and drugs. It's a tough thing to say, but from experience, not having contact with SIL #2 and her boyfriend is going to be the easiest, safest path for Isabella, and if that path includes the passing of two people who can not stay sober, then so be it, it's all about Isabella.
I'm sure you and your wife have discussed what happens if the miracle occurs, and one/both of her biological parents actually gets sober and leads a productive life. There is no easy solution and of course, Isabella will be stuck in the middle.
I can't say enough about your wife and yourself. The pictures that you have posted of Isabella have just melted me, and since I am aware of Isabella's situation, I pray nothing but the best for Isabella. I know Isabella is in great hands, and I pray that everything turns out OK for Isabella, and I pray that part of everything being OK for Isabella, doesn't hurt you or your wife in any way. Thank you and your wife for being such decent people, Isabella deserves better, and she now has better!
I wish nothing but the best for the you, your wife and, of course, Isabella. Best of Luck!
Scott
BTW, at about age 11, the pink starts turning to garnet and gold!