After Pete's death, Jessie finds comfort in Rick, who makes sure she and her son Ron are looked after. Grateful for his continued support, Jessie kisses Rick, leading to the pair's romantic involvement. Their relationship was brief, because while trying to outrun zombies in Alexandria Safe-Zone, Jessie becomes swarmed. In fear, she refuses to let go of Carl's hand. To save Carl from being eaten (as Ron was), Rick cuts off Jessie's hand and the zombies attack and kill her.
In later issues, Rick confesses that he cared for Jessie and was deeply pained to lose her.